Initial revelations about Avengers: Doomsday suggest Shuri is the one who discovers the multiverse is collapsing, and that framing puts her on a familiar, and dangerous, path within the MCU.
HBO's Lanterns used a season-defining twist in its very first episode, and a single line in the midseason trailer indicates that the obvious read may not be the right one.
A script that's been floating around online for years claims to show how George R.R. Martin actually wanted Game of Thrones to end, and it has almost nothing in common with what HBO put on screen.